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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMEK1
All Species:
44.85
Human Site:
T264
Identified Species:
82.22
UniProt:
Q6IN85
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6IN85
NP_115949.3
833
95368
T264
L
K
Q
K
I
H
Q
T
Y
R
V
Q
Y
I
Q
Chimpanzee
Pan troglodytes
XP_001140788
1051
117499
T495
L
K
Q
K
I
H
Q
T
Y
R
V
Q
Y
I
Q
Rhesus Macaque
Macaca mulatta
XP_001112386
1020
115840
T437
L
R
Q
K
I
H
Q
T
Y
R
V
Q
Y
I
Q
Dog
Lupus familis
XP_854423
820
93834
T264
L
K
Q
K
I
H
Q
T
Y
R
V
Q
Y
I
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q6P2K6
820
93824
T264
L
K
Q
K
I
H
Q
T
Y
R
V
Q
Y
I
Q
Rat
Rattus norvegicus
NP_001101837
820
93952
T266
L
R
Q
K
I
H
Q
T
Y
R
V
Q
Y
I
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506908
818
93822
T264
L
K
Q
K
I
H
Q
T
Y
R
V
Q
Y
I
Q
Chicken
Gallus gallus
XP_421321
821
93987
T264
L
K
Q
K
I
H
Q
T
Y
R
V
Q
Y
I
Q
Frog
Xenopus laevis
Q6INN7
822
94182
T264
L
K
Q
K
I
H
Q
T
Y
R
V
Q
Y
I
Q
Zebra Danio
Brachydanio rerio
Q5SP90
818
93771
T264
L
R
Q
K
I
H
Q
T
Y
R
V
Q
Y
I
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFS5
980
109277
T267
L
L
A
K
I
H
Q
T
F
R
V
Q
Y
I
Q
Honey Bee
Apis mellifera
XP_393542
775
88267
R243
K
R
H
R
E
Y
L
R
Q
L
A
R
F
K
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40164
858
98034
C293
L
K
I
I
M
K
K
C
F
R
L
Q
F
L
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78
59.7
97.8
N.A.
97.7
73.3
N.A.
94.1
96
89.9
87.6
N.A.
49.2
58.7
N.A.
N.A.
Protein Similarity:
100
78
69.7
98.3
N.A.
98.1
85.5
N.A.
95.6
97.2
94.8
93.6
N.A.
66.2
73.5
N.A.
N.A.
P-Site Identity:
100
100
93.3
100
N.A.
100
93.3
N.A.
100
100
100
93.3
N.A.
80
6.6
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
86.6
40
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
41.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
0
0
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
16
0
0
0
16
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
8
0
0
85
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
8
85
0
0
0
0
0
0
0
0
85
0
% I
% Lys:
8
62
0
85
0
8
8
0
0
0
0
0
0
8
8
% K
% Leu:
93
8
0
0
0
0
8
0
0
8
8
0
0
8
0
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
77
0
0
0
85
0
8
0
0
93
0
0
93
% Q
% Arg:
0
31
0
8
0
0
0
8
0
93
0
8
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
85
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
85
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
77
0
0
0
85
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _